姓名：李英奇

职称：教授，博士生导师

联系方式：wkyqli@sxu.edu.cn

介绍：

主要从事纳米材料的功能化及其在生物成像和靶向抗肿瘤效应以及在生物分子等检测方面的研究；金属离子与具有生物功能蛋白之间的作用。在国内外核心刊物上发表学术论文60余篇，授权国家发明专利7项，2018年获山西省模范教师。2019年和2011年分别获山西省科学技术奖(自然科学类）和山西省高等学校科学技术奖(自然科学类)二等奖。2018 年硕士研究生荣获2017年山西省优秀硕士学位论文。为国际期刊Small, ACS Applied Materials & Interfaces，Analytical Chemistry，Current Drug Delivery等期刊审稿。

学习与工作经历：

2001年7月至今在化学化工学院从事教学和科研工作，一直致力于对功能化纳米材料的表面构建及其抗肿瘤效应、 纳米团簇在生物分子的检测及肿瘤细胞识别中的应用等方面的研究工作。2003年9月至2006年7月在山西大学分子科学研究所读博士，获博士学位。2007年11月至2008年10月，进行博士后工作。2019年9月至2020年9月在加拿大温莎大学做访问学者。

讲授课程：结构化学，结构化学实验

研究方向：从事化学与生物学交叉领域，属于物理化学/无机化学/制药工程专业，研究方向主要包括：

（1）功能化纳米材料及生物效应研究。

（2）纳米材料用于生物传感研究

主持科研项目：

1. 科技部专项基金项目，研发靶向和双开关型纳米钻石药物-乳腺癌“狙击手”的技术创兴平台，2019-01至2021-12

2．山西省重点研发项目（社会发展），GSH调控的纳米钻石药物体系对肿瘤诊疗一体化研究，2019-12至2021-12

3. 山西省重点研发项目（社会发展），2016年中西药优化与应用研究-多功能纳米钻石药物的开发及其高效治疗肿瘤的应用，2016-07至2018-12

4. 山西省仪器设备购置及升级改造专项基金，2014.1-12

5. 山西省重点研发项目，恶性肿瘤发病机制及生物治疗的研究-荧光纳米钻石的肿瘤靶向检测和抗肿瘤活性研究，2013-01至2015-12

6. 国家自然科学基金面上项目，靶向和缓释双功能抗癌纳米钻石材料的制备及其生物效应研究，2010-01至2013-12

7. 山西省回国留学人员科研资助项目，具有靶向抗癌功能纳米钻石材料的制备及其生物效应研究，2010-01至2012-12

8. 山西省自然科学基金面上项目，2009011012-3，转铁蛋白纳米靶向载药系统制备及细胞内转运机理研究，2009-01至2012-12

9. 山西省自然科学青年基金，新型抗癌剂Ga（III）－铁传递蛋白与肝癌细胞的作用机制，2005-06-2007-12

代表性论文：

1. Xiangbin Du, Lin Li, Shiguo Wei, Songbai Wang and Yingqi Li*, A tumor-targeted, intracellular activatable and theranostic nanodiamond drug platform for strongly enhanced in vivo antitumor therapy, J. Mater. Chem. B，2020, 8, 1660.

2. Xiangping Wen, Zhonghua Zhao, Shuqin Zhai, Xiedong Wang, Yingqi Li*, Stable nitrogen and sulfur co-doped carbon dots for selective folate sensing, in vivo imaging and drug delivery, Diam. Relat. Mater., 2020, 105, 107791.

3. Wei Shiguo; Li Lin; Du Xiangbin; Li Yingqi*; OFF–ON nanodiamond drug platform for targeted cancer imaging and therapy, J. Mater. Chem. B, 2019, 7, 3390.

4. Zhao Hemiao; Wen Xiangping; Li Wenyan; Li Yingqi*; Yin Caixia*; A copper-mediated on–off–on gold nanocluster for endogenous GSH sensing to drive cancer cell recognition, J. Mater. Chem. B,2019, 7, 2169.

5. Lu Tian, Wenjing Zhao, Lin Li, Yaoli Tong, Guanlin Peng, Yingqi Li*, Multi-talented applications for cell imaging, tumor cells recognition, patterning, staining and temperature sensing by using egg white-encapsulated gold nanoclusters, Sensor. Actuat. B-Chem. 2017, 240, 114.

6. Wenjing Zhao, Shiguo Wei, Hemiao Zhao, Yingqi Li*, Ruifang Wu, Juanjuan Wang, Enhanced anticancer activity of an intracellularly activatable nanomedicine based on GLYlated nanodiamond, Diam. Relat. Mater., 2017, 77, 171.  

7. Lu Tian, Yangfan Li, Tingting Ren, Yaoli Tong, Binsheng Yang, Yingqi Li*, Novel bimetallic gold-silver nanoclusters with “synergy”-enhanced fluorescence for cyanide sensing, cell imaging and temperature sensing, Talanta, 2017, 170, 530.

8. Lin Li, Lu Tian, Yongli Wang, Wenjing Zhao, Fangqin Cheng, Yingqi Li*, Binsheng Yang*, Smart pH-responsive and high doxorubicin loading nanodiamond for in vivo selective targeting, imaging, and enhancement of anticancer therapy, J. Mater. Chem. B, 2016, 4, 5046.

9. Bin Liu, Xiangquan Hu, Jie Chai, Junyao Zhu, Binsheng Yang*, Yingqi Li*, Application of nanodiamonds in Cu(II)-based rhodamine B probes for NO detection and cell imaging, J. Mater. Chem. B, 2016, 4, 3358.

10. Lin Li, Lu Tian, Wenjing Zhao, Yingqi Li*, Binsheng Yang*, Acetate ions enhance load and stability of doxorubicin onto PEGylated nanodiamond for selective tumor intracellular controlled release and therapy, Integr. Biol., 2016, 8, 956.

11. Lin Li, Lu Tian, Wenjing Zhao, Fangqin Cheng, Yingqi Li*, Binsheng Yang*, pH-sensitive nanomedicine based on PEGylated nanodiamond for enhanced tumor therapy, RSC Adv., 2016, 6, 36407.

12. Yu Dong, Ruixia Cao, Yingqi Li^*, Zhiqin Wang, Lin Li, Lu Tian, Folate-conjugated nanodiamond for tumor targeted drug delivery, RSC Adv., 2015, 5, 82711.

13. ZhiqinWang, Zhimei Tian, Yu Dong, Lin Li, Lu Tian, Yingqi Li*, Binsheng Yang, Nanodiamond-conjugated transferrin as chemotherapeutic drug delivery, Diam. Relat. Mater., 2015, 58, 84.

14. Yingqi Li*, Yaoli Tong, Ruixia Cao, Zhimei Tian, Binsheng Yang, Pin Yang, In vivo enhancement of anticancer therapy using bare or chemotherapeutic drug-bearing nanodiamond particles, Int. J. Nanomed., 2014, 9, 1065.

15. Dongxin Wang, Yingqi Li*, Ruixia Cao, Zhimei Tian, Binsheng Yang*, Transferrin-conjugated nanodiamond as intracellular transporter of chemotherapeutic drug and targeting therapy for Cancer Cells, Ther. Deliv., 2014, 5, 511.

16. Dongxin Wang, Yaoli Tong, Yingqi Li*, Zhimei Tian, Ruixia Cao, Binsheng Yang*, PEGylated nanodiamond for chemotherapeutic drug delivery, Diam. Relat. Mater., 2013, 36, 26.

17. Dongxin Wang, Yingqi Li*, Binsheng Yang*. Interaction between Fluorescent  Nanodiamond and Human Transferrin and Intracellular Imaging. Acta Chim. Sinica，2013, 71, 782.

18. Yuejun Fu, Nan An, Shuhua, Zheng, Aihua Liang, Yingqi Li*, BmK CT-conjugated fluorescence nanodiamond as potential glioma-targeted imaging and drug, Diam. Relat. Mater., 2012, 21, 73.

19. Yingqi Li*, Xueping Zhou, Dongxing Wang, Binsheng Yang*, Pin Yang, Nanodiamond mediated delivery of chemotherapeutic drugs, J. Mater. Chem., 2011, 21, 16406.

20. Yingqi Li*, Xueping Zhou, Transferrin-coupled fluorescence nanodiamonds as targeting intracellular transporters: An investigation of the uptake mechanism, Diam. Relat. Mater., 2010, 19, 1163.

21. Yingqi Li*, Xueping Zhou, Xueying Ren，Xine Duan, Effect of Eu³⁺ on the conformation of apoovotransferrin，Acta Chim. Sinica, 2010, 68, 1027.

22. Yingqi Li，Bin Liu，Binsheng Yang*, Spectroscopic analysis of the interaction between chromium (III) and apoovotransferrin，J. Lumin.，2010，130, 2339.

授权专利：

1. 一种磁靶向纳米钻石药物及其制备方法和应用，ZL201610067837.7.

2. 高负载及pH可控释放阿霉素的纳米钻石药物制备和应用，ZL201510591826.4.

3. 一种以腙键连接的纳米钻石药物及其制备方法和应用，ZL201510291034.5.

4.一种酯键偶联纳米钻石阿霉素药物及其制备方法和应，ZL201510291057.6

5. 纳米钻石表面修饰负载甲氨蝶呤的药物及其制备方法， ZL201510005266.X.

6. 叶酸修饰的纳米钻石靶向药物的制备方法和应用，ZL201410006838.1.

7. 一种靶向纳米钻石载体和靶向药物及其制备方法和应用，ZL 201310124917.8