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姓名:刘景

职称:教授

联系方式:liujing4203@sxu.edu.cn

介绍:

刘景,女,1987年生,中共党员,理学博士,教授,博士生导师。20147月留校任教并获得山西省优秀博士学位论文201612月破格晋升为教授。本人长期从事小分子生物硫醇、生物活性氧/活性氮荧光探针以及新型近红外荧光染料的研究工作,以第一作者或通讯作者身份在JACS, Angew, Chem.Sci., Biomaterials等国际著名期刊共发表SCI论文20余篇,他引频次3000余次,单篇最高引用次数为431次,3篇论文被ESI列为前1%高引论文。2016年获得山西省科学技术奖自然科学类二等奖(3/6),入选山西省第六批青年拔尖人才支持计划(2018),山西省 三晋英才支持计划拔尖骨干人才(2018),山西省高等学校优秀青年学术带头人(2019)。荣获2019年度山西大学十佳青年教师和第六届五四青年奖章。主要学术兼职为山西省生物工程学会精准医学与伴随诊断专委会委员。

学习与工作经历:

2016/12 – 至今,山西大学,化学化工学院,教授

2014/07 – 2016/11,山西大学,化学化工学院,讲师

2009/09 2014/07,山西大学,博士

2005/09 2009/07,长治学院,学士

讲授课程:有机化学、无机及分析化学实验

研究方向:分子识别与生物传感

主持科研项目:

1.山西省高等学校优秀青年学术带头人,2019.07-2021.12,20万元,主持

2.山西省青年拔尖人才,2019.01-2021.12,60万元,主持

3.国家自然科学基金青年科学基金,2016.01-2018.12,卤代吡啰红荧光染料平台的构建及其在荧光探针方面的应用,21万元,主持

4.山西省应用基础研究项目,2016.08-2018.12,卤代吡啰红荧光染料平台在荧光探针的构建及生物传感方面的应用,4万元,主持

5.山西省高等学校创新人才支持计划,2016.04-2018.04,生物活性物质荧光探针的构建及生物传感研究,2万元,主持

代表性论文:

1. Jing Liu, Mengxing Liu, Hongxing Zhang and Wei Guo*, High-Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on beta-Lapachone-Triggered ROS Amplification Specific in Cancer Cells, Angew. Chem. Int. Ed., 2021, DOI: 10.1002/anie.202102377.

2. Linfang Wang, Jing Liu*, Hongxing Zhang and Wei Guo*, Discrimination between cancerous and normal cells/tissues enabled by a near-infrared fluorescent HClO probe, Sensors and Actuators B: Chemical, 2021, 334, 129602.

3. Yan Song, Hongxing Zhang, Xia Wang, Xin Geng, Yuanqiang Sun*, Jing Liu*, and Zhaohui Li, One Stone, Three Birds: pH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization, Anal. Chem., 2021, 93, 1786.

4. Hongxing Zhang, Jing Liu*, Yuanqiang Sun, Mengxing Liu and Wei Guo*, Carbon–Dipyrromethenes: Bright Cationic Fluorescent Dyes and Potential Application in Revealing Cellular Trafficking of Mitochondrial Glutathione Conjugates, J. Am. Chem. Soc. 2020, 40, 17069.

5. Linfang Wang, Jing Liu*, Shengwei Zhao, Hongxing Zhang, Yuanqiang Sun, Aihua Wei and Wei Guo*, Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm, Chem. Commun., 2020, 56, 7718.

6. Jing Liu, Mengxing Liu, Hongxing Zhang, Xuehong Wei, Juanjuan Wang, Ming Xian and Wei Guo*, Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine, Chemical Science, 2019, 10, 10065.

7. Hongxing Zhang, Jing Liu, Bo Hu, Linfang Wang, Z Yang, Xu Han, Juanjuan Wang, Wei Bai, Wei Guo*, Dual-Channel Fluorescence Diagnosis of Cancer Cells/Tissues Assisted by OATP Transporters and Cysteine/Glutathione, Chemical Science, 2018, 9, 3209. (共同第一作者)

8. Hongxing Zhang, Jing Liu, Linfang Wang, Minjia Sun, Xiaohan Yan, Juanjuan Wang, Jianping Guo, Wei Guo*, Amino-Si-rhodamines: A new class of two-photon fluorescent dyes with intrinsic targeting ability for lysosomes, Biomaterials, 2018, 158, 10. (共同第一作者)

9. Hongxing Zhang, Jing Liu, Chenlu Liu, Pengcheng Yu, Minjia Sun, Xiaohan Yan, Jian-Ping Guo*, Wei Guo,* Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near infrared fluorescent probe, Biomaterials, 2017, 133, 60. (共同第一作者)

10. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Heping Shi, Yawei Shi, and Wei Guo.* Sulfone-Rhodamines: A New Class of Near-Infrared Fluorescent Dyes for Bioimaging, ACS Appl. Mater. Interfaces. 2016, 8, 22953.

11. Hongxing Zhang, Jing Liu, Yuan-Qiang Sun, Yingying Huo, Yaohua Li, Weizhi Liu, Xiao Wu, Nishu Zhu, Yawei Shi and Wei Guo*, A mitochondria-targetable fluorescent probe for peroxynitrite: fast response and high selectivity, Chem. Commun., 2015, 51, 2721. (共同第一作者)

12. Jing Liu, Yuan-Qiang Sun, YingYing Huo, HongXing Zhang, LinFang Wang, Pei Zhang, Dan Song, YaWei Shi, Wei Guo*, Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels, J. Am. Chem. Soc. 2014,136, 574.

13. Jing Liu, Yuan-Qiang Sun, HongXing Zhang, YingYing Huo, YaWei Shi, Wei Guo*, Simultaneous Fluorescent Imaging of Cys/Hcy and GSH from Different Emission Channels, Chemical Science, 2014, 5, 3183.

14. Yuan-Qiang Sun, Jing Liu, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*, A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione, J. Am. Chem. Soc., 2014, 136, 12520. (共同第一作者)

15. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, Heping Shi and Wei Guo*, A carboxylic acid-functionalized coumarinhemicyanine fluorescent dye and its application to construct a fluorescent probe for selective detection of cysteine over homocysteine and glutathione, RSC Advances, 2014, 4, 64542.

16. Jing Liu, Yuan-Qiang Sun, JingYu Zhang, Ting Yang, JianBin Chao, LiShen Zhang, W. Guo*, A ratiometric fluorescent probe for biological signaling molecule H2S: fast response and high selectivity, Chemistry-A European Journal, 2013,19, 4717.

17. Jing Liu, Yuan-Qiang Sun, Pi Wang, JingYu Zhang, Wei Guo*, Construction of NIR and ratiometric fluorescent probe for Hg2+ based on a rhodamine-inspired dye platform, Analyst, 2013,138, 2654.

18. Jing Liu, Yuan-Qiang Sun, Xin Lv, Wei Guo*, Fluoreascent detection of biothiols based on a novel cascade reaction, Analytical Methods, 2013, 5, 3642.

19. Yuan-Qiang Sun, Jing Liu, JingYu Zhang, Ting Yang, Wei Guo*, Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite, Chem. Commun., 2013, 49, 2637. (共同第一作者)

20. Yuan-Qiang Sun, Jing Liu, Xin Lv, YunLong Liu, Yun Zhao, Wei Guo*, Rhodamine-Inspired Far-Red to Near-Infrared Dyes and Their Application as Fluorescence Probes, Angew. Chem. Int. Ed., 2012, 51, 7634.

21. Yuan-Qiang Sun, Jing Liu, Pi Wang, JingYu Zhang, Wei Guo*, D-Luciferin Analogues: a Multicolor Toolbox for Bioluminescence Imaging, Angew. Chem. Int. Ed., 2012, 51, 8428.


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