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姓名:冯丽恒

职称:教授

联系方式:lhfeng@sxu.edu.cn


简 介:

1979年生,山西交城人,工学博士,教授,博士生导师。山西大学校学术委员会委员,化学学科分学术委员会副主任委员,化学化工学院副院长,教师第一党支部支部书记。青年三晋学者特聘教授,山西省高等学校中青年拔尖人才,山西省高等学校优秀青年学术带头人,“131”工程中青年拔尖人才及三晋英才优秀青年人才。中国化学学会委员,山西省纳米医药组委会委员,山西省生物工程学会精准医疗与伴随诊断专委会委员。获得山西省自然科学二等奖,山西省优秀博士论文获得者。


学习与工作经历:

2014/12 – 至今,山西大学,化学化工学院,教授

2012/03 – 2014/02,中国科学院化学研究所,博士后

2009/10 – 2014/11,山西大学,化学化工学院,副教授

2007/07 2009/09,山西大学,化学化工学院,讲师

2002/09 – 2007/06,山西大学,化学化工学院,博士(硕博连读)

1998/09 – 2002/06,山西大学,化学化工学院,学士


工作职责:分管学院学科建设和人才工作


讲授课程:《有机化学》、《基础有机化学实验》


招生研究生:有机化学专业博士和硕士研究生、制药工程专业硕士研究生


研究方向:

有机共轭分子材料的制备及应用研究。提出了解决抗菌耐药性关键科学问题的新策略;发展了彻底治愈恶性肿瘤的新技术;阐明了恶性肿瘤难以彻底治愈的根源;明确了病原菌耐药性的作用机制;揭示了有机功能分子与细菌、肿瘤细胞相互作用的方式;搭建了自组装体多功能药物向临床应用初步探索的桥梁。


主持科研项目:

1、 国家自然科学基金(面上项目), 2020.1-2023.12

2、 国家自然科学基金(面上项目), 2016.1-2019.12

3、国家自然科学基金(面上项目), 2014.1-2017.12

4、国家自然科学基金(青年), 2009.1-2011.12

5、三晋学者特聘教授专项基金,2018.1-2022.12

6、山西青高等学校中青年拔尖人才专项基金,2017.7-2020.12

7、山西省优秀青年科技基金,2014.1-2016.12

8、山西省高等学校优秀青年学术带头人专项基金,2013.5-2016.5

9、中国博士后科学基金特别资助,2013.1-2014

10、中国博士后科学面上二等资助,2012.6-2013.6

11、山西省自然科学基金(青年),2009.1-2011.12


代表性论文:

1. Liheng Feng, Chunlei Zhu, Huanxiang Yuan, Libing Liu*, FengtingLv, Shu Wang*, Conjugated Polymer Nanoparticles: Preparation, Properties, Functionalization and Biological Applications, Chem. Soc. Rev., 2013, 42, 6620. IF=40.44

2. Liheng Feng, Libing Liu, Fengting Lv, Guollermo C. Bazan*, Shu Wang*, Preparation and Biofunctionalization of Multicolor Conjugated Polymer Nanoparticles for Imaging and Detection of Tumor Cells, Adv. Mater., 2014, 26, 3926. IF=25.81

3. Yunxia Wang, Shengliang Li*, Pengbo Zhang, Haotian Bai, Liheng Feng, Fengting Lv, Libing Liu*, Shu Wang*, Photothermal-responsive Conjugated Polymer Nanoparticles for Remote Control of Gene Expression in Living Cells, Adv. Mater., 2018, 1705418. IF=25.81

4. Fengyan Wang, Zhang Liu, Bing Wang, Liheng Feng, Libing Liu*, Fengting Lv, Yilin Wang*, Shu Wang*, Multi-color Fibers by Self-assembly of DNA, Histone Proteins and Cationic Conjugated Polymers, Angew. Chem. Int. Ed., 2014, 53, 424. IF=12.26

5. Jinzhao Song, Jiangyan Zhang, Fengting Lv*, Yongqiang Cheng, Bing Wang, Liheng Feng, Libing Liu, Shu Wang*, Multiplex Detection of DNA Mutations by Fluorescence Fingerprint Spectrum Technique, Angew. Chem. Int. Ed., 2013, 52, 3020. IF=12.26

6. Yunxia Wang, Liheng Feng*, Shu Wang*, Conjugated Polymer Nanoparticles for Imaging, Cell Activity Regulation, and Therapy, Adv. Funct. Mater., 2019, 29, 1806818. IF=15.62

7. Meng Li#, Liheng Feng#, Haiyan Lu,* Shu Wang,* Chuanfeng Chen*, Tetrahydro[5]helicene-Based Nanoparticles for Structure-Dependent Cell Fluorescent Imaging, Adv. Funct. Mater., 2014, 24, 4405. IF=15.62

8. Liheng Feng*, Lixia Guo, Xiaoju Wang*, Preparation, Properties and Applications in Cell Imaging and Ions Detection of Conjugated Polymer Nanoparticles with Alcoxyl Bonding Fluorene Core, Biosens. Bioelectron., 2017, 87, 514. IF=9.52

9. Lixia Guo, Haoping Wang, Yunxia Wang,* Feng Liu,* Liheng Feng*, Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials ACS Appl. Mater. Interfaces, 2020, DOI. 10.1021/acsami.9b19921. IF=8.46

10. Yunxia Wang, Haoping Wang, Lixia Guo, Yuehong Pang,* Liheng Feng*, Red Fluorescence Conjugated Polymer with Broad Spectrum Antimicrobial Activity for Treatment of Bacterial Infections in Vivo, ACS Appl. Mater. Interfaces, 2018, 10, 34878. IF=8.46

11. Liheng Feng*, Jiarong Zhu, Zhijun Wang*, Biological Functionalization of Conjugated Polymer Nanoparticles for Targeted Imaging and Photodynamic Killing of Tumor Cells, ACS Appl. Mater. Interfaces, 2016, 8, 19364. IF=8.46

12. Yunxia Wang, Shengliang Li, Liheng Feng, Chenyao Nie, Libing Liu,* Fengting Lv, and Shu Wang*, Fluorescence Ratiometric Assay Strategy for Chemical Transmitter of Living Cells Using H2O2Sensitive Conjugated Polymers, ACS Appl. Mater. Interfaces, 2015, 7, 24110. IF=8.46

13. Chenyao Nie, Chunlei Zhu, Liheng Feng, Fengting Lv*, Libing Liu, Shu Wang*, Synthesis of a New Conjugated Polymer for DNA Alkylation and Gene Regulation, ACS Appl. Mater. Interfaces, 2013, 5, 4549. IF=8.46

14. Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*, Tailor-Made Polymer Nano-Assembly with Switchable Function and Amplified Anti-Tumor Therapy, Adv. Healthc. Mater., 2019, 9, 1901492. IF=6.27

15. Sirong Zhou, Changgang Yang, Lixia Guo, Yunxia Wang*, Guofeng Zhang*, Liheng Feng*, Water-soluble Conjugated Polymer with Near-infrared Absorption for Synergistic Tumor Therapy Using Photothermal and Photodynamic Activity, Chem. Comm., 2019, 55, 8615. IF=6.16

16. Zhenkang Wen,* Zekai Zhao, Ningjing Wang, Ziling Chen, Jianbin Chao, Liheng Feng*, Palladium-Catalyzed Controllable Reductive/Oxidative Heck Coupling between Cyclic Enones and Thiophenes via C−H Activation, Org. Lett., 2019, 21, 9545. IF=6.55

17. Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*, Facile Core–shell Nanoparticles with Controllable Antibacterial Activity Assembled by Chemical and Biological Molecules, Biomater. Sci., 2019, 7, 5528. IF=5.25

18. Haoping Wang, Lixia Guo, Yunxia Wang*, Liheng Feng*, Bactericidal Activity-tunable Conjugated Polymers as a Human-friendly Bactericide for the Treatment of Wound Infections, Biomater. Sci., 2019, 7, 3788. IF=5.25

19. Sirong Zhou, Zhijun Wang, Yunxia Wang,* Liheng Feng*, Near-Infrared Light-Triggered Synergistic Phototherapy for Antimicrobial Therapy, ACS Appl. Bio Mater., 2020, 3, 1730.

20. Yunxia Wang, Shengliang Li, Libing Liu,* Liheng Feng*, Photothermal-Responsive Conjugated Polymer Nanoparticles for the Rapid and Effective Killing of Bacteria, ACS Appl. Bio Mater., 2018, 1, 27.


授权专利:

1. 冯丽恒, 郭丽霞. 一种环状聚合物及其制备方法和应用,中国发明专利,授 权日2020.2.14,专利号:ZL201810189654.1

2. 冯丽恒, 王皓萍. 一种光动力杀菌聚合物及其制备方法和应用,中国发明专利,授权日2020.1.3,专利号:ZL201810189651.8

3. 冯丽恒, 邓杨.一种红光发射聚合物及制备方法,中国发明专利,授权日2018.4.24,专利号:ZL201610552452.X

4. 冯丽恒,殷宁华,王晓菊. 一种检测连翘酯苷A的组合物及其制备方法,中国发明专利,授权日2017.12.5,专利号:ZL201510169890.3

5. 冯丽恒, 郭丽霞. 一种蓝光发光材料及其制备方法,中国发明专利,授权日2017.11.3,专利号:ZL20161020923.0

6. 王晓菊, 赵三虎, 张立伟, 冯丽恒. 一种双核苯并咪唑离子盐及其制备方法和应用,中国发明专利,授权日2016.9.28,专利号:ZL201510005233.5

7. 王晓菊, 魏超飞, 冯丽恒. 一种3-(溴代苯基)-2,2’-二氟丙酸的制备方法,中国发明专利,授权日2016.5.11,专利号:ZL201510005147.4

8. 李猛, 王树, 冯丽恒, 陈传峰. 有机荧光染料分子及其合成方法和应用, 中国发明专利,授权日2015.10.28,专利号:ZL20161020923.0

9. 刁海鹏, 刘文, 冯丽恒, 解军. 一种6-氨基-5--1-异吲哚啉酮的制备方法,中国发明专利,授权日2014.1.15,专利号,ZL201210421516.4

10. 冯丽恒,孙玥,牛伟平,梁飞. 2-氰基-5-氨基嘧啶的制备方法,中国发明专利,授权日2013.2.23,专利号:ZL201110169997.X

11. 冯丽恒,段炼,王越,徐明,殷宁华. 一种检测D-果糖的组合物及其制备方法,中国发明专利,授权日2013.1.2,专利号:ZL201110166960.1

12. 赵三虎,王晓菊,牛伟平,冯丽恒. 一种含有蒽功能团的水溶性聚合物及其制备方法,中国发明专利,授权日2012.12.5,专利号,ZL201110279953.2

13. 陈兆斌,冯丽恒. 一种含有电子注入传输基团的金属络合物型发光材料及其制备方法,中国发明专利,授权日2006.12.6,专利号:ZL200410012447.4

14. 冯丽恒,陈兆斌. 一种含有空穴传输基团的金属络合物型发光材料及其制备方法,中国发明专利,授权日2006.7.12,专利号:ZL200410012446.2



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