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姓名:郭 炜

职称:教 授(二级)

联系方式:guow@sxu.edu.cn

介绍:

主要从事荧光染料、探针的开发及生物医学应用研究,在JACS、Angew. Chem. Int. Ed.、Chem. Sci.、Biomaterials、ACS Appl. Mater. Interfaces、Chem. Commun.、Org. Lett.、Anal. Chem.等国际学术期刊发表论文60余篇,他引3500余次,主持国家自然科学基金6项,研究项目“荧光探针的构建及生物传感研究”获山西省科学技术(自然科学类)二等奖;入选教育部新世纪优秀人才、山西省高等学校中青年拔尖创新人才、山西省学术技术带头人、三晋英才拔尖骨干人才、第八届山西省优秀科技工作者、山西省研究生教育优秀导师;现为中国化学会理事、山西省化学会常务理事、山西省精准医疗与伴随诊断委员会副主委、山西大学学术委员会委员、山西省有机化学重点学科带头人、Spectrochimica Acta Part A编委。

学习与工作经历:

2002/07 – 至今,山西大学,化学化工学院

1999/09 – 2002/07,南开大学,博士

1995/09 – 1998/07,山西大学,硕士

1991/09 – 1995/07,山西大学,学士


工作职责:


全面主持学院行政管理工作、主持学院党委全面工作

讲授课程:

高等有机化学、物理有机化学

研究方向:

荧光染料、探针的开发及生物医学应用

主持科研项目:

1. 国家自然科学基金,有机阴离子转运多肽调控的近红外吡啰红衍生物肿瘤荧光诊断与治疗试剂的开发及应用,2019/01-2022/12;

2.国家自然科学基金,一氧化氮其下游产物过氧亚硝基新型有机荧光探针的构建及生物传感研究,2016/01-2019/12;2. 

3. 国家自然科学基金,通键能量转移(TBET)近红外荧光功能分子的构建及化学传感研究,2012/01-2015/12;

4. 国家自然科学基金,罗丹明传感器的设计、合成及在离子传感、生物细胞中离子成像方面的应用,2011/01-2011/12;

5. 国家自然科学基金,新型Tripodal氧杂、氮杂醚类化合物的构建以及对阳离子的选择性识别研究,2008/01-2010/12;

6. 国家自然科学基金,新型有机负氢转移试剂,N1,N2-二取代的咪唑啉啶在有机合成中的应用研究,2006/01-2008/12.

代表性论文:

[1] Xin Lv,Chunmei Gao, Taihe Han, Hu Shi and Wei Guo*; Improving the quantum yields of fluorophores by inhibiting twisted intramolecular charge transfer using electron-withdrawing group-functionalized piperidine auxochromes; Chem. Commun., 2020, 56, 715-718.

[2] Hu Shi,* Hao Li, Wenlong Gong, Ruiting Gong, Aniu Qian, Jin Yong Lee, and Wei Guo*; Structural and Binding Properties on Ab Mature Fibrils Due to the Histidine Tautomeric Effect, ACS Chem. Neurosci., 2019, 10, 4612−4618.

[3] Minghao Ren, Linfang Wang, Xin Lv, Yuanqiang Sun, Hu Chen, Keyuan Zhang, Qi Wu, Yurong Bai and Wei Guo*; A rhodol-hemicyanine based ratiometric fluorescent probe for real-time monitoring of glutathione dynamics in living cells; Analyst, 2019, 144, 7457–7462.

[4] Jing Liu, Mengxing Liu, Hongxing Zhang, Xuehong Wei, Juanjuan Wang, Ming Xian* and Wei Guo*; Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine; Chem. Sci., 2019, 10, 10065–10071.

[5] Minghao Ren, Linfang Wang, Xin Lv,* Jing Liu, Hu Chen, Juanjuan Wang and Wei Guo*; Development of a benzothiazole-functionalized red-emission pyronin dye and its dihydro derivative for imaging lysosomal viscosity and tracking endogenous peroxynitrite; J. Mater. Chem. B, 2019, 7, 6181-6186.

[6] Yingying Huo, Junfeng Miao, Junru Fang, Hu Shi, Juanjuan Wang, and Wei Guo*; Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies; Chem. Sci., 2019, 10, 145–152.

[7] Junfeng Miao, Yingying Huo, Hu Shi, Junru Fang, Juanjuan Wang, and Wei Guo*; A Si-rhodamine-based near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and animals; J. Mater. Chem. B, 2018, 6, 4466-4473.

[8] Hongxing Zhang, Jing Liu, Bo Hu, Linfang Wang, Zhen Yang, Xu Han, Juanjuan Wang, Wei Bai, and Wei Guo*; Dual-Channel Fluorescence Diagnosis of Cancer Cells/Tissues Assisted by OATP Transporters and Cysteine/Glutathione; Chem. Sci., 2018, 9, 3209–3214.

[9] Hongxing Zhang, Jing Liu, Linfang Wang, Minjia Sun, Xiaohan Yan, Juanjuan Wang, Jian-Ping Guo, and Wei Guo*; Amino-Si-Rhodamines: a New Class of Two-Photon Fluorescent Dyes with Intrinsic Targeting Ability for Lysosomes; Biomaterials, 2018, 158, 10-22.

[10] Xin Lv,* Xia Yuan, Yue Wang and Wei Guo*; A naphthalimide based fast and selective fluorescent probe for hypochlorous acid/hypochlorite and its application for bioimaging; New J. Chem., 2018, 42, 15105-15110.

[11] Yingying Huo, Junfeng Miao, Lingjun Han, Yaping Li, Zhe Li, Yawei Shi, and Wei Guo*; Selective and Sensitive Visualization of Endogenous Nitric Oxide in Living Cells and Animals by a Si-Rhodamine Deoxylactam-Based Near-Infrared Fluorescent Probe; Chem. Sci., 2017, 8, 6857-6864.

[12] Hongxing Zhang, Jing Liu, Chenlu Liu, Pengcheng Yu, Minjia Sun, Xiaohan Yan, Jian-Ping Guo, Wei Guo*; Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near-infrared fluorescent probe; Biomaterials, 2017, 133, 60-69.

[13] Yun Zhao*, Yuanyuan Xue, Haoyang Li, Ruitao Zhu Yuehong Ren, Qinghua Shi, Song Wang, Wei Guo*; An excited state intramolecular proton transfer dye based fluorescence turn-on probe for fast detection of thiols and its applications in bioimaging; Spectrochim. Acta, Part A, 2017, 175, 215-221.

[14] Yue Wang, Xin Lv*, Wei Guo**; A reaction-based and highly selective fluorescent probe for hydrogen sulfide; Dyes and Pigments, 2017, 139, 482-486.

[15] Yingying Huo, Junfeng Miao, Yaping Li, Yawei Shi, Heping Shi and Wei Guo*; Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms; J. Mater. Chem. B, 2017, 5, 2483-2490.

[16] Junfeng Miao, Yingying Huo, Qian Liu, Zhe Li, Heping Shi, Yawei Shi, and Wei Guo*; A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats; Biomaterials, 2016, 107, 33-43.

[17] Junfeng Miao, Yingying Huo, Xin Lv, Zhe Li, Hualiang Cao, Heping Shi, Yawei Shi, and Wei Guo*; Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines; Biomaterials, 2016, 78, 11.

[18] Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Heping Shi, Yawei Shi, and Wei Guo*; Sulfone-Rhodamines: A New Class of Near-Infrared Fluorescent Dyes for Bioimaging; ACS Applied Materials & Interfaces. 2016, 8, 22953.

[19] Jian Zhang, Yaping Li, Jingjing Zhao, and Wei Guo*; An arylboronate-based fluorescent probe for selective and sensitive detection of peroxynitrite and its applications for fluorescence imaging in living cells; Sensors and Actuators B, 2016, 237, 67–74.

[20] Yue Wang, Yawei Liu, Junfeng Miao, Minghao Ren, Wei Guo, Xin Lv*; A novel Bodipy-based fluorescent probe for Au3+ ions with high selectivity and its application to bioimaging; Sensors and Actuators B, 2016, 226, 364–369.

[21] Yun Zhao, Yuehong Ren, Haoyang Li, Taihe Han, Huanhuan Chen, Wei Guo*; A new far-red naphthorhodamine dye: Synthesis, fluorescent probe and bioimaging applications; Dyes and Pigments, 2016, 132, 255-261.

[22] Yawei Liu, Xin Lv, Min Hou, Yawei Shi, and Wei Guo*; Selective Fluorescence Detection of Cys over Hcy and GSH Based on a Cys-Triggered Dual Michael Addition/Retro-aza-aldol Cascade Reaction; Anal. Chem., 2015, 87, 11475.

[23] Yawei Liu, Xin Lv, Jing Liu, Yuan-Qiang Sun, and Wei Guo*; Construction of a Selective Fluorescent Probe for GSH Based on a Chloro-functionalized Coumarin-enone Dye Platform; Chem. Eur. J., 2015, 21, 4747.

[24] Hongxing Zhang, Jing Liu Yuan-Qiang Sun, Yingying Huo, Yaohua Li, Weizhi Liu, Xiao Wu, Nishu Zhu, Yawei Shi, and Wei Guo*; A Mitochondria-Targetable Fluorescent Probe for Peroxynitrite: Fast Response and High Selectivity; Chem. Commun., 2015, 51, 2721.

[25] Xin Lv, Yue Wang, Song Zhang, Yawei Liu, Jian Zhang and Wei Guo*; A specific fluorescent probe for NO based on a new NO-binding group; Chem. Commun., 2014, 50, 7499.

[26] Yuan-Qiang Sun, Jing Liu, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*; A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione; J. Am. Chem. Soc., 2014, 136, 12520.

[27] Yawei Liu, Song Zhang, Xin Lv, Yuan-Qiang Sun, Jing Liu, and Wei Guo*; Constructing fluorescent probe for specific detection of cysteine over homocysteine and glutathione based on a novel cysteine-binding group but-3-yn-2-one; Analyst, 2014, 139, 4081.

[28] Jing Liu, Yuan-Qiang Sun, Yingying Huo, Hongxing Zhang, Linfang Wang, Pei Zhang, Yawei Shi, and Wei Guo*; Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels; J. Am. Chem. Soc., 2014, 136, 574.

[29] Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, Heping Shi, and Wei Guo*; A Carboxylic acid-Functionalized Coumarin-Hemicyanine Fluorescent Dye and Its Application to Construct a Fluorescent Probe for Selective Detection of Cysteine over Homocysteine and Glutathione; RSC Adv., 2014, 4, 64542.

[30] Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, and Wei Guo*; Simultaneous Fluorescent Imaging of Cys/Hcy and GSH from Different Emission Channels; Chem. Sci., 2014, 5, 3183.

[31] Jingyu Zhang and Wei Guo*; A new fluorescent probe for gasotransmitter H2S: high sensitivity and selectivity, and a significant fluorescence off–on response; Chem. Commun., 2014, 50, 4214.

[32] Jingyu Zhang, Yuan-Qiang Sun, Jing Liu, Yawei Shi and Wei Guo*; A fluorescent probe for the biological signaling molecule H2S based on a specific H2S trap group; Chem. Commun., 2013, 49, 11305.

[33] Jing Liu, Yuan-Qiang Sun, Pi Wang, Jingyu Zhang and Wei Guo*; Construction of NIR and Ratiometric Fluorescent Probe for Hg2+ Based on a Rhodamine-Inspired Dye Platform; Analyst, 2013, 138, 2654.

[34] Jing Liu, Yuan-Qiang Sun, Jingyu Zhang, Ting Yang, Jianbin Cao, Lishen Zhang, and Wei Guo*; A Ratiometric Fluorescent Probe for Biological Signaling Molecule H2S: Fast Response and High Selectivity; Chem. Eur. J., 2013, 19, 4717.

[35] Yuan-Qiang Sun,za Jing Liu,za Jingyu Zhang,a Ting Yangb and Wei Guo*; Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite; Chem. Commun., 2013, 49, 2637.

[36] Jing Liu, Yuan-Qiang Sun, Xin Lv, and Wei Guo*; Fluorescent detection of biothiols based on a novel cascade reaction; Anal. Methods, 2013, 5, 3642.

[37] Yuan-Qiang Sun, Pi Wang, Jing Liu, Jingyu Zhang and Wei Guo*; A fluorescent turn-on probe for bisulfite based on hydrogen bond-inhibited C=N isomerization mechanism; Analyst, 2012, 137, 3430.

[38] Yuan-Qiang Sun, Jing Liu, Pi Wang, Jingyu Zhang, and Wei Guo*; D-Luciferin Analogues: a Multicolor Toolbox for Bioluminescence Imaging; Angew. Chem. Int. Ed., 2012, 51, 8428.

[39] Yuan-Qiang Sun, Jing Liu, Xin Lv, Yunlong Liu, Yun Zhao, and Wei Guo*; Rhodamine-Inspired Far-Red to Near-Infrared Dyes and Their Application as Fluorescence Probes; Angew. Chem. Int. Ed. 2012, 51, 7634.

[40] Yun Zhao, Xin Lv, Yunlong Liu, Jing Liu, Yan Zhang, Heping Shi, and Wei Guo*; The emission enhancement of the NIR distyryl Bodipy dyes by the indirected S0→S2 excitation and its application towards Hg2+ probe; J. Mater. Chem. 2012, 22, 11475.

[41] Xianshu Zhou, Xin Lv, Junsheng Hao, Diansheng Liu, Wei Guo*; Coumarin-indanedione conjugate as a doubly activated Michael addition type probe for the colorimetric and ratiometric fluorescent detection of cyanide; Dyes and Pigments 2012, 95, 168.

[42] Xianshu Zhou, Hengquan Yang, Junsheng Hao, Caixia Yin, Diansheng Liu,* and Wei Guo*; A Fluorescence Turn-on Sensor for CN‾ Based on Exciplex Signaling Mechanism; Chem. Lett. 2012, 41, 518.

[43] Pi Wang, Jing Liu, Xin Lv, Yunlong Liu, Yun Zhao, and Wei Guo*; A Naphthalimide-based Glyoxal Hydrazone for Selective Fluorescence Turn-on Sensing of Cys and Hcy; Org. Lett. 2012, 14, 520.

[44] Yunlong Liu, Xin Lv, Yun Zhao, Maliang Chen, Jing Liu, Pi Wang and Wei Guo*; A naphthalimide-rhodamine ratiometric fluorescent probe for Hg2+ based on fluorescence resonance energy transfer; Dyes and Pigments 2012, 92, 909.

[45] Yunlong Liu, Xin Lv, Yun Zhao, Jing Liu, Yuan-Qiang Sun, Pi Wang and Wei Guo*; A Cu(II)-based chemosensing ensemble bearing rhodamine B fluorophore for fluorescence turn-on detection of cyanide; J. Mater. Chem. 2011, 22, 1747.

[46] Xin Lv, Jing Liu, Yunlong Liu, Yun Zhao, Yuan-Qiang Sun, Pi Wang and Wei Guo*; Ratiometric fluorescent detection of cyanide based a hybrid coumarin-hemicyanine dye: the large emission shift and the high selectivity; Chem. Commun. 2011, 47, 12843.

[47] Yuan-Qiang Sun, Maliang Chen, Jing Liu, Xin Lv, Jun-fei Li and Wei Guo*; Nitroolefin-based coumarin as a colorimetric and fluorescent dual probe for biothiols; Chem. Commun. 2011, 47, 11029.

[48] Yun Zhao, Yan Zhang, Xin Lv, Yunlong Liu, Maliang Chen, Pi Wang, Jing Liu and Wei Guo*; Through-bond energy transfer cassettes based on coumarin-bodipy/distyryl bodipys dyads with efficient energy efficiences and large pseudo-Stokes’ shift; J. Mater. Chem. 2011, 21, 13168.

[49] Xin Lv, Jing Liu, Yunlong Liu, Yun Zhao, Maliang Chen, Pi Wang and Wei Guo*; Rhodafluor-based Chromo- and Fluorogenic Probe for Cyanide Anion; Sensors and Actuators B 2011, 158, 405.

[50] Xin Lv, Jing Liu, Yunlong Liu, Yun Zhao, Maliang Chen, Pi Wang and Wei Guo*; A Ratiometric Fluorescent Probe for Cyanide Based on FRET; Org. Biomol. Chem. 2011, 9, 4954.

[51] Maliang Chen, Xin Lv, Yunlong Liu, Yun Zhao, Jing Liu, Pi Wang and Wei Guo*; An 2-(2'-aminophenyl)benzoxazole-based OFF-ON fluorescent chemosensor for Zn2+ in aqueous solution; Org. Biomol. Chem 2011, 9, 2345.

[52] Yunlong Liu, Yue Sun, Jun Du, Xin Lv, Yun Zhao, Maliang Chen, Pi Wang, and Wei Guo*; Highly Sensitive and Selective Turn-on Fluorescent and Chromogenic Probe for Cu2+ and ClO¯ Based on a N-Picolinyl Rhodamine B-Hydrazide Derivative; Org. Biomol. Chem. 2011, 9, 432.

[53] Yun Zhao, Yue Sun,  Xin Lv, Yunlong Liu, Maliang Chen, and Wei Guo*; Rhodamine-based chemosensor for Hg2+ in aqueous solution with abroad pH range and its application in live cell imaging; Org. Biomol. Chem. 2010, 8, 4143.

[54] Yue Sun, Yunlong Liu, Maliang Chen and Wei Guo*; A novel fluorescent and chromogenic probe for cyanide detection in water based on the nucleophilic addition of cyanide to imine group; Talanta 2009, 80, 996.

[55] Yue Sun, Yunlong Liu and Wei Guo*; Fluorescent and chromogenic probes bearing salicylaldehyde hydrazone functionality for cyanide detection in aqueous solution; Sensors and Actuators B 2009, 143, 171.

[56] Yongbin Zhang, Guofu Zhou, Donghong Li, Wei Guo*; Tetrahydropyrimidine Derivatives as Efficient Organic Reductants for Transfer Hydrogenation; Heterocycles, 2009, 78, 1541.

[57] Yue Sun, Guofeng, Wang, Wei Guo*; Colorimetric Detection of Cyanide with N-Nitrophenyl Benzamide Derivatives; Tetrahedron, 2009, 65, 3480.



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