姓名：郭 炜

职称：教 授（二级）

联系电话：0351-7198890

联系方式：guow@sxu.edu.cn

介绍：

        郭炜，男，1972年生，博士，二级教授，博士生导师。现任山西大学化学化工学院党委书记，兼任山西省化学会理事长、中国化学会理事、中国感光学会光化学与光生物专业委员会委员、山西省精准医疗与伴随诊断专业委员会副主委、光转换功能分子山西省重点实验室主任、山西省科技创新人才团队—领军团队—带头人。入选教育部新世纪优秀人才、山西省学术技术带头人等人才计划。主要从事荧光传感与光动力治疗研究，迄今在Chem. Soc. Rev.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Coord. Chem. Rev.、Chem. Sci.、Biomaterials等国际权威期刊发表学术论文80余篇，他引5000余次；获批中国发明专利6项；主持国家自然科学基金7项、中央引导地方科技发展资金项目1项；获山西省科学技术二等奖2 项、山西省教学成果特等奖1项、一等奖2项。

学习与工作经历：

2021/10-至今，山西大学，化学化工学院，党委书记。

2017/05-2021/10，山西大学，化学化工学院，院长。

2017/12-至今，山西大学，化学化工学院，二级教授。

2007/05-2017/05，山西大学，化学化工学院，副院长。

2006/12-2017/12，山西大学，化学化工学院，教授。

2006/06-至今，山西大学，化学化工学院，博士生导师。

2004/12-2006/12，山西大学，化学化工学院，副教授。

2002/07-2004/12，山西大学，化学化工学院，讲师。

1999/09-2002/07，南开大学，化学系，博士生。

1998/07-1999/09，山西大学，化学系，助教。

1995/09-1998/07，山西大学，化学系，硕士生。

1991/09-1995/07，山西大学，化学系，本科生。

工作职责：

全面主持学院党委全面工作

讲授课程：

高等有机化学、物理有机化学

研究方向：

荧光传感与光动力治疗

主持科研项目：

1、国家自然科学基金，菁酮法构建中位立体位阻芳基取代的七甲川花菁近红外荧光染料及肿瘤荧光诊断与光动力治疗研究，2022/01-2025/12；

2、中央引导地方科技发展资金项目，肿瘤靶向近红外光动力治疗试剂的开发及应用，2021/08-2023/12；

3、国家自然科学基金，有机阴离子转运多肽调控的近红外吡啰红衍生物肿瘤荧光诊断与治疗试剂的开发及应用，2019/01-2022/12；

4、国家自然科学基金，一氧化氮其下游产物过氧亚硝基新型有机荧光探针的构建及生物传感研究，2016/01-2019/12；

5、国家自然科学基金，通键能量转移（TBET）近红外荧光功能分子的构建及化学传感研究，2012/01-2015/12；

6、国家自然科学基金，罗丹明传感器的设计、合成及在离子传感、生物细胞中离子成像方面的应用，2011/01-2011/12；

7、国家自然科学基金，新型Tripodal氧杂、氮杂醚类化合物的构建以及对阳离子的选择性识别研究，2008/01-2010/12；

8、国家自然科学基金，新型有机负氢转移试剂，N1,N2-二取代的咪唑啉啶在有机合成中的应用研究，2006/01-2008/12。

代表性论文：

[1] Zhen Yang, Jing Liu,* Hongxing Zhang, Mengxing Liu, Meixin Liu, Yanrong Li, Yuan-Qiang Sun,* Wei Guo,* Conformationally restrained coumarin hemicyanines: Improved quantum yields and potential applications in bioimaging and photodynamic therapy, Sensors & Actuators: B. Chemical 2023, 387, 133832.

[2] Yuanqiang Sun, Pengjuan Sun, Zhaohui Li*, Lingbo Qu and Wei Guo*, Natural flavylium-inspired far-red to NIR-II dyes and their applications as fluorescent probes for biomedical sensing, Chem. Soc. Rev., 2022, 51, 7170-7205.

[3] Junfeng Miao, Yingying Huo,* Guangxiao Yao, Yu Feng, Jiajin Weng, Wei Zhao, and Wei Guo*, Heavy Atom-Free, Mitochondria-Targeted, and Activatable Photosensitizers for Photodynamic Therapy with Real-Time In-Situ Therapeutic Monitoring, Angew. Chem. Int. Ed., 2022, e202201815.

[4] Xin Lv,* Taihe Han, Yi Wu, Boran Zhang and Wei Guo*, Improving the fluorescence brightness of distyryl Bodipys by inhibiting the twisted intramolecular charge transfer excited state, Chem. Commun., 2021, 57, 9744–9747.

[5] Jing Liu, Mengxing Liu, Hongxing Zhang, and Wei Guo*, High-Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on b-Lapachone-Triggered ROS Amplification Specific in Cancer Cells, Angew. Chem. Int. Ed., 2021, 60, 12992–12998.

[6] Yuanqiang Sun, Pengjuan Sun, and Wei Guo*, Fluorescent probes for iron, heme, and related enzymes, Coord. Chem. Rev., 2021, 429, 213645.

[7] Xin Lv, Taihe Han, Xia Yuan, Hu Shi and Wei Guo*, Design, synthesis, and bioimaging applications of a new class of carborhodamines, Analyst, 2021, 146, 64–68.

[8] Hongxing Zhang, Jing Liu,* Yuan-Qiang Sun, Mengxing Liu, and Wei Guo*, Carbon-Dipyrromethenes: Bright Cationic Fluorescent Dyes and Potential Application in Revealing Cellular Trafficking of Mitochondrial Glutathione Conjugates, J. Am. Chem. Soc., 2020, 142, 17069−17078.

[9] Xin Lv, Chunmei Gao, Taihe Han, Hu Shi and Wei Guo*, Improving the quantum yields of fluorophores by inhibiting twisted intramolecular charge transfer using electron-withdrawing group-functionalized piperidine auxochromes, Chem. Commun., 2020, 56, 715−718.

[10] Jing Liu, Mengxing Liu, Hongxing Zhang, Xuehong Wei, Juanjuan Wang, Ming Xian* and Wei Guo*, Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine, Chem. Sci., 2019, 10, 10065–10071.

[11] Yingying Huo, Junfeng Miao, Junru Fang, Hu Shi, Juanjuan Wang, and Wei Guo*; Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies; Chem. Sci., 2019, 10, 145–152.

[12] Junfeng Miao, Yingying Huo, Hu Shi, Junru Fang, Juanjuan Wang, and Wei Guo*; A Si-rhodamine-based near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and animals; J. Mater. Chem. B, 2018, 6, 4466–4473.

[13] Hongxing Zhang, Jing Liu, Bo Hu, Linfang Wang, Zhen Yang, Xu Han, Juanjuan Wang, Wei Bai, and Wei Guo*; Dual-Channel Fluorescence Diagnosis of Cancer Cells/Tissues Assisted by OATP Transporters and Cysteine/Glutathione; Chem. Sci., 2018, 9, 3209–3214.

[14] Hongxing Zhang, Jing Liu, Linfang Wang, Minjia Sun, Xiaohan Yan, Juanjuan Wang, Jian-Ping Guo, and Wei Guo*; Amino-Si-Rhodamines: a New Class of Two-Photon Fluorescent Dyes with Intrinsic Targeting Ability for Lysosomes; Biomaterials, 2018, 158, 10−22.

[15] Yingying Huo, Junfeng Miao, Lingjun Han, Yaping Li, Zhe Li, Yawei Shi, and Wei Guo*; Selective and Sensitive Visualization of Endogenous Nitric Oxide in Living Cells and Animals by a Si-Rhodamine Deoxylactam-Based Near-Infrared Fluorescent Probe; Chem. Sci., 2017, 8, 6857−6864.

[16] Hongxing Zhang, Jing Liu, Chenlu Liu, Pengcheng Yu, Minjia Sun, Xiaohan Yan, Jian-Ping Guo, Wei Guo*; Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near-infrared fluorescent probe; Biomaterials, 2017, 133, 60−69.

[17] Junfeng Miao, Yingying Huo, Qian Liu, Zhe Li, Heping Shi, Yawei Shi, and Wei Guo*; A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats; Biomaterials, 2016, 107, 33−43.

[18] Junfeng Miao, Yingying Huo, Xin Lv, Zhe Li, Hualiang Cao, Heping Shi, Yawei Shi, and Wei Guo*; Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines; Biomaterials, 2016, 78, 11-19.

[19] Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Heping Shi, Yawei Shi, and Wei Guo*; Sulfone-Rhodamines: A New Class of Near-Infrared Fluorescent Dyes for Bioimaging; ACS Applied Materials & Interfaces. 2016, 8, 22953−22962.

[20] Yawei Liu, Xin Lv, Min Hou, Yawei Shi, and Wei Guo*; Selective Fluorescence Detection of Cys over Hcy and GSH Based on a Cys-Triggered Dual Michael Addition/Retro-aza-aldol Cascade Reaction; Anal. Chem., 2015, 87, 11475−11483.

[21] Yuan-Qiang Sun, Jing Liu, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*; A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione; J. Am. Chem. Soc., 2014, 136, 12520.

[22] Jing Liu, Yuan-Qiang Sun, Yingying Huo, Hongxing Zhang, Linfang Wang, Pei Zhang, Yawei Shi, and Wei Guo*; Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels; J. Am. Chem. Soc., 2014, 136, 574.

[23] Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, and Wei Guo*; Simultaneous Fluorescent Imaging of Cys/Hcy and GSH from Different Emission Channels; Chem. Sci., 2014, 5, 3183.

[24] Jing Liu, Yuan-Qiang Sun, Pi Wang, Jingyu Zhang and Wei Guo*; Construction of NIR and Ratiometric Fluorescent Probe for Hg2+ Based on a Rhodamine-Inspired Dye Platform; Analyst, 2013, 138, 2654.

[25] Jing Liu, Yuan-Qiang Sun, Jingyu Zhang, Ting Yang, Jianbin Cao, Lishen Zhang, and Wei Guo*; A Ratiometric Fluorescent Probe for Biological Signaling Molecule H2S: Fast Response and High Selectivity; Chem. Eur. J., 2013, 19, 4717.

[26] Yuan-Qiang Sun,za Jing Liu,za Jingyu Zhang,a Ting Yangb and Wei Guo*; Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite; Chem. Commun., 2013, 49, 2637.

[27] Yuan-Qiang Sun, Jing Liu, Pi Wang, Jingyu Zhang, and Wei Guo*; D-Luciferin Analogues: a Multicolor Toolbox for Bioluminescence Imaging; Angew. Chem. Int. Ed., 2012, 51, 8428.

[28] Yuan-Qiang Sun, Jing Liu, Xin Lv, Yunlong Liu, Yun Zhao, and Wei Guo*; Rhodamine-Inspired Far-Red to Near-Infrared Dyes and Their Application as Fluorescence Probes; Angew. Chem. Int. Ed. 2012, 51, 7634.

[29] Pi Wang, Jing Liu, Xin Lv, Yunlong Liu, Yun Zhao, and Wei Guo*; A Naphthalimide-based Glyoxal Hydrazone for Selective Fluorescence Turn-on Sensing of Cys and Hcy; Org. Lett. 2012, 14, 520.

授权专利：

[1]中国发明专利（ZL202110285928.9），一种高对比度区分癌细胞/组织的方法及荧光探针的制备（郭炜，刘景，张洪星）；

[2]中国发明专利（ZL201810470830.9），一种近红外碳罗丹明荧光染料及其合成方法（吕鑫，袁霞，郭炜）；

[3]中国发明专利（ZL202011471554.1），Zn²⁺比率荧光探针制备及应用（刘景，张洪星，郭炜）；

[4]中国发明专利（ZL202011354574.0），基于吡罗红肼的HClO荧光探针制备及应用（刘景，王林芳，郭炜）；

[5]中国发明专利（ZL202011361513.7），基于吡罗红肟的近红外HClO荧光探针制备及其应用（刘景，王林芳，郭炜）；

[6]中国发明专利（ZL2003101166881），2-氰基吩噻嗪的制备方法（郭炜，吴维维，李歆，王长生，范宁娟，夏炽中）；

[7]中国发明专利（ZL200410012337.0），乙二醇二芳醚的制备方法（郭炜，夏炽中）；

[8]中国发明专利（ZL202110285928.9），一种高对比度区分癌细胞/组织的方法及荧光探针的制备（郭炜，刘景，张洪星）。