姓名：张洪星

职称：副教授

联系方式：15035171156

邮箱：hxzhang4714@sxu.edu.cn

介绍：

       张洪星，男，1988年生，理学博士，硕士生导师。主要从事荧光染料及荧光探针的开发，致力于新型荧光染料的合成、活性硫化物（ROS）和活性氧/氮化物（ROS/RNS）的传感及生物影像研究，在 J.   Am.   Chem.   Soc、  Ang  ew. Chem. Int. Ed、  Chem. Sci.  、  Biomaterials  、  Chem. Commun 等国内外重要学术杂志上发表论文20余篇。

学习与工作经历：

2021/12– 至今，山西大学，化学化工学院，副教授

2018/07 – 2021/12，山西大学，化学化工学院，讲师

2015/09 – 2018/07，山西大学，博士

2012/09 – 2015/07，山西大学，硕士

2008/09 – 2012/07，山西大学，学士

研究方向：

荧光染料、探针的开发及生物医学应用

讲授课程：

有机化学

主持科研项目：

1、国家自然科学基金青年科学基金，2021.01-2023.12，卤线粒体靶向的水溶性“碳-双吡咯甲烷（Carbodipy）”正离子型荧光染料的设计、合成、光物理性质研究以及在肿瘤光动力治疗方面的应用，主持

2、山西省高等学校创新人才支持计划，2019-2021，主持

代表性论文：

1. Hongxing Zhang, Guoxi Ren, Wenhua Hou, Lijuan Wang, Yuan-Qiang Sun,* and Jing Liu,* A Silicon-Rhodamine-Based Heavy-Atom-Free Photosensitizer for Mitochondria-targeted Photodynamic Therapy,  Spectrochim. Acta A Mol. Biomol. Spectrosc. , 2024, 308, 123688.

2. Zhen Yang, Jing Liu,* Hongxing Zhang, Mengxing Liu, Meixin Liu, Yanrong Li, Yuan-Qiang Sun,* Wei Guo,* Conformationally restrained coumarin hemicyanines: Improved quantum yields and potential applications in bioimaging and photodynamic therapy,  Sensors & Actuators: B. Chemical , 2023, 387, 133832.

3. Jing Liu, Mengxing Liu, Hongxing Zhang and Wei Guo*, High-Contrast Fluorescence Diagnosis of Cancer Cells/Tissues Based on beta-Lapachone-Triggered ROS Amplification Specific in Cancer Cells,  Angew. Chem. Int. Ed. , 2021, DOI: 10.1002/anie.202102377.

4. Linfang Wang, Jing Liu*, Hongxing Zhang and Wei Guo*, Discrimination between cancerous and normal cells/tissues enabled by a near-infrared fluorescent HClO probe, Sensors and Actuators B: Chemical , 2021, 334 ,  129602.

5. Yan Song, Hongxing Zhang, Xia Wang, Xin Geng, Yuanqiang Sun*, Jing Liu*, and Zhaohui Li, One Stone, Three Birds: pH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization,  Anal. Chem ., 2021, 93, 1786.

6. Xing Wei , Hongxing Zhang, Yuanqiang Sun, Jing Liu, Zhaohui Li, Engineering a lipid droplet targeting fluorescent probe with a large Stokes shift through ester substituent rotation for in vivo tumor imaging,  Analyst, 2021, 146, 495–501.

7. Pengjuan Sun, Hongxing Zhang, Yuanqiang Sun, Jing Liu, The recent development of fluorescent probes for the detection of NADH and NADPH in living cells and in vivo,  Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy , 2021, 245, 118919

8. Hongxing Zhang, Jing Liu*, Yuanqiang Sun, Mengxing Liu and Wei Guo*, Carbon–Dipyrromethenes: Bright Cationic Fluorescent Dyes and Potential Application in Revealing Cellular Trafficking of Mitochondrial Glutathione Conjugates,  J. Am. Chem. Soc . 2020, 40, 17069.

9. Linfang Wang, Jing Liu*, Shengwei Zhao, Hongxing Zhang, Yuanqiang Sun, Aihua Wei and Wei Guo*, Fluorescence imaging of hypochlorous acid and peroxynitrite in vitro and in vivo with emission wavelength beyond 750 nm,  Chem. Commun ., 2020, 56, 7718.

10. Jing Liu, Mengxing Liu, Hongxing Zhang, Xuehong Wei, Juanjuan Wang, Ming Xian and Wei Guo*, Exploring cysteine regulation in cancer cell survival with a highly specific “Lock and Key” fluorescent probe for cysteine,  Chemical Science , 2019, 10, 10065.

11. Hongxing Zhang, Jing Liu, Bo Hu, Linfang Wang, Z Yang, Xu Han, Juanjuan Wang, Wei Bai, Wei Guo*, Dual-Channel Fluorescence Diagnosis of Cancer Cells/Tissues Assisted by OATP Transporters and Cysteine/Glutathione,  Chemical Science , 2018, 9, 3209.

12. Hongxing Zhang, Jing Liu, Linfang Wang, Minjia Sun, Xiaohan Yan, Juanjuan Wang, Jianping Guo, Wei Guo*, Amino-Si-rhodamines: A new class of two-photon fluorescent dyes with intrinsic targeting ability for lysosomes,  Biomaterials , 2018, 158, 10.

13. Hongxing Zhang, Jing Liu, Chenlu Liu, Pengcheng Yu, Minjia Sun, Xiaohan Yan, Jian-Ping Guo*, Wei Guo,* Imaging lysosomal highly reactive oxygen species and lighting up cancer cells and tumors enabled by a Si-rhodamine-based near infrared fluorescent probe,  Biomaterials , 2017, 133, 60.

14. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Heping Shi, Yawei Shi, and Wei Guo.* Sulfone-Rhodamines: A New Class of Near-Infrared Fluorescent Dyes for Bioimaging,  ACS Appl. Mater. Interfaces . 2016, 8, 22953.

15. Hongxing Zhang, Jing Liu, Yuan-Qiang Sun, Yingying Huo, Yaohua Li, Weizhi Liu, Xiao Wu, Nishu Zhu, Yawei Shi and Wei Guo*, A mitochondria-targetable fluorescent probe for peroxynitrite: fast response and high selectivity,  Chem. Commun ., 2015, 51, 2721.

16. Jing Liu, Yuan-Qiang Sun, YingYing Huo, HongXing Zhang, LinFang Wang, Pei Zhang, Dan Song, YaWei Shi, Wei Guo*, Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels,  J. Am. Chem. Soc . 2014,136, 574.

17. Jing Liu, Yuan-Qiang Sun, HongXing Zhang, YingYing Huo, YaWei Shi, Wei Guo*, Simultaneous Fluorescent Imaging of Cys/Hcy and GSH from Different Emission Channels,  Chemical Science, 2014, 5, 3183.

18. Yuan-Qiang Sun, Jing Liu, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*, A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione,  J. Am. Chem. Soc. , 2014, 136, 12520.

19. Jing Liu, Yuan-Qiang Sun, Hongxing Zhang, Yingying Huo, Yawei Shi, Heping Shi and Wei Guo*, A carboxylic acid-functionalized coumarinhemicyanine fluorescent dye and its application to construct a fluorescent probe for selective detection of cysteine over homocysteine and glutathione,  RSC Advances , 2014, 4, 64542.

授权专利：

1、张洪星、刘景，一种荧光探针及其制备方法和应用，中国发明专利，ZL202210588887.5，授权日期：2023年12月26日。

2、张洪星、刘景、郭炜，一种线粒体粘度探针及其制备方法和应用，ZL202111028020.6，中国发明专利，授权日期：2022年5月27日。

3、张洪星、刘景，一种极性荧光探针及其制备方法和应用，中国发明专利，ZL202111027991.9，授权日期：2022年5月31日。