姓名：霍莹莹

职称：副教授

联系方式：18035176576

邮箱：1002893432@qq.com

介绍：

    开发了多种新型光敏剂，具有优异的光物理化学性质和生物相容性，可高效产生活性氧，用于肿瘤的光动力治疗。对染料分子进行功能化修饰，赋予其新的性质和功能，拓展其在生物成像、疾病诊断和治疗等领域的应用。检测气体信使分子NO荧光探针的设计合成和生物应用。 研究结果分别以第一作者发表在Angew. Chem. Int. Ed, Biomaterials，Chem. Sci.，ACS Appl. Mater. Interfaces 和J. Mater. Chem. B上。

学习与工作经历：

2018/08 – 至今，山西大学，化学化工学院

2012/09 – 2018/07，山西大学，硕博连读

2008/09 – 2012/07，山西大学，学士

讲授课程：

生物化学、分子影像学

研究方向：

有机小分子荧光探针、检测气体信使分子NO的荧光探针、新型光化学治疗的光敏试剂、染料的功能化修饰及其生物应用

主持科研项目：

1. 国家自然青年基金，“芳香二级胺”型近红外一氧化氮荧光探针的构建及在肿瘤免疫治疗研究中的应用, 24 万，2020.1-2022.12，结题

代表性论文：

1. Constructing Heavy-Atom-Free Photosensitizers for Hypoxic Tumor Phototherapy Based on Donor-Excited Photoinduced Electron-Transfer-Driven Type-I and Type-II Mechanisms. Junfeng Miao, Guangxiao Yao, Yingying Huo*, Beibei Wang, Wei Zhao, and Wei Guo*. ACS Applied Materials & Interfaces 2024 16 (31), 40428-40443.

2. Heavy Atom-Free, Mitochondria-Targeted, and Activatable Photosensitizers for Photodynamic Therapy with Real-Time In-Situ Therapeutic Monitoring. Junfeng Miao, Yingying Huo*, Guangxiao Yao, Yu Feng, Jiajin Weng, Wei Zhao, and Wei Guo*. Angew. Chem. Int. Ed. 2022, 61, e202201815.

3. Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies，Yingying Huo, Junfeng Miao, Junru Fang, Hu Shi, Juanjuan Wang and Wei Guo*，Chem. Sci., 2019, 10, 145-152.

4. Selective and sensitive visualization of endogenous nitric oxide in living cells and animals by a Sirhodamine deoxylactam-based near-infrared fluorescent probe，Yingying Huo, Junfeng Miao, Lingjun Han, Yaping Li, Zhe Li, Yawei Shi and Wei Guo *, Chemical Science, 2017, 8, 6857-6864.

5. Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms, Yingying Huo, Junfeng Miao, Yaping Li, Yawei Shi, Heping Shi and Wei Guo*, J. Mater. Chem. B, 2017, 5, 2483—2490.

6. Fast-response and highly selective fluorescent probes for biological signaling molecule NO based-on N-nitrosation of electron-rich aromatic secondary amines, Junfeng Miao, Yingying Huo, Xin Lv, Zhe Li, Hualiang Cao, Heping Shi, Yawei Shi, Wei Guo *, Biomaterials, 2016,78, 11-19.

7. A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats, Junfeng Miao, Yingying Huo, Qian Liu, Zhe Li, Heping Shi, Yawei Shi, Wei Guo*, Biomaterials, 2016, 107, 33-43.

8. A Si-rhodamine-based near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and animals，Junfeng Miao, Yingying Huo, Hu Shi, Junru Fang, Juanjuan Wang and Wei Guo*，J. Mater. Chem. B, 2018, 6, 4466—4473.

9. “Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels” Jing Liu, Yuan-Qiang Sun, Yingying Huo, Hongxing Zhang, Linfang Wang, Pei Zhang, Dan Song, Yawei Shi, and Wei Guo*, J. Am. Chem. Soc., 2014, 136, 574−577.

10. “A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione”, Yuan-Qiang Sun, Jing Liu, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*, J. Am. Chem. Soc., 2014, 136, 12520−12523.