姓名：霍莹莹

职称：副教授

联系方式：18035169530

邮箱：huoying0107@outlook.com

介绍：

      检测气体信使分子NO荧光探针的设计合成和生物应用,以及新型光化学治疗的光敏试剂的开发。 研究结果分别以第一作者发表在Chemical Science(IF=9.556), JMCB(IF=4.543)上。

学习与工作经历：

2018/08 – 至今，山西大学，化学化工学院

2012/09 – 2018/07，山西大学，硕博连读

2008/09 – 2012/07，山西大学，学士

讲授课程：

生物化学

研究方向：

有机小分子荧光探针

主持科研项目：

1. 国家自然青年基金，2020.1-2022.12；

代表性论文：

1. Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies，Yingying Huo^‡, Junfeng Miao^‡, Junru Fang, Hu Shi, Juanjuan Wang and Wei Guo*，Chem. Sci., 2019, 10, 145-152.

2. Selective and sensitive visualization of endogenousnitric oxide in living cells and animals by a Sirhodamine deoxylactam-based near-infrared fluorescent probe，Yingying Huo^‡, Junfeng Miao^‡, Lingjun Han, Yaping Li, Zhe Li, Yawei Shi and Wei Guo *, Chemical Science, 2017, 8, 6857-6864.

3. Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms, Yingying Huo^‡, Junfeng Miao^‡, Yaping Li, Yawei Shi, Heping Shi and Wei Guo*, J. Mater. Chem. B, 2017, 5, 2483—2490.

4. Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines, Junfeng Miao^‡, Yingying Huo^‡, Xin Lv, Zhe Li, Hualiang Cao, Heping Shi, Yawei Shi, Wei Guo *, Biomaterials, 2016,78, 11-19.

5. A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats, Junfeng Miao^‡, Yingying Huo^‡, Qian Liu, Zhe Li, Heping Shi, Yawei Shi, Wei Guo*,Biomaterials, 2016, 107, 33-43.

6. A Si-rhodamine-based near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and animals，Junfeng Miao^‡, Yingying Huo^‡, Hu Shi, Junru Fang, Juanjuan Wang and Wei Guo*，J. Mater. Chem. B, 2018, 6, 4466—4473.

7. “Simultaneous Fluorescence Sensing of Cys and GSH from Different Emission Channels” Jing Liu^‡, Yuan-Qiang Sun^‡, Yingying Huo, Hongxing Zhang, Linfang Wang, Pei Zhang, Dan Song, Yawei Shi, and Wei Guo*, J. Am. Chem. Soc., 2014, 136, 574−577.

8. “A Mitochondria-Targetable Fluorescent Probe for Dual-Channel NO Imaging Assisted by Intracellular Cysteine and Glutathione”, Yuan-Qiang Sun^‡, Jing Liu^‡, Hongxing Zhang, Yingying Huo, Xin Lv, Yawei Shi, and Wei Guo*, J. Am. Chem. Soc., 2014, 136, 12520−12523.

9. “Simultaneous fluorescent imaging of Cys/Hcy and GSH from different emission channels”, Jing Liu^‡, Yuan-Qiang Sun^‡, Hongxing Zhang, Yingying Huo, Yawei Shi and Wei Guo*, Chem. Sci., 2014, 5, 3183-3188.

10. “A mitochondria-targetable fluorescent probe for peroxynitrite: fast response and high selectivity”, Hongxing Zhang^‡, Jing Liu^‡, Yuan-Qiang Sun, Yingying Huo,Yaohua Li, Weizhi Liu, Xiao Wu, Nishu Zhu, Yawei Shi and Wei Guo*, Chem. Commun., 2015, 51, 2721.

11. “A carboxylic acid-functionalized coumarinhemicyanine fluorescent dye and its application to construct a fluorescent probe for selective detection of cysteine over homocysteine and glutathione”, Jing Liu^‡, Yuan-Qiang Sun^‡, Hongxing Zhang, Yingying Huo, Yawei Shi, Heping Shi and Wei Guo*, RSC Adv., 2014, 4, 64542.