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姓名:石虎

职称:讲师

联系方式:17535153919

邮箱:hshi@sxu.edu.cn

介绍:

石虎,博士学位,致力于计算生物学与计算材料学基础研究。其研究在J. Am. Chem. Soc.、ChemBiomaterialsChem. Comm.ACS Chem. Neurosci.等国际权威学术期刊发表学术论文20余篇。曾在韩获得“Research Excellence Award in 2016”(2017)“2017年国家优秀自费留学生(2018)

(热烈欢迎有志于科研事业的学子报考本实验室硕士研究生,2020年计划招收1-2名研究生,欢迎报考!欢迎本科生跟组实验!) (M.S. students who are loving chemistry and chemical research are welcomed to join our group.)

学习与工作经历:

2017/12 – 至今   山西大学 (Shanxi Univ.),化学化工学院,讲师

2017/06 – 2017/11 韩国成均馆大学和基础科学研究院,博士后

2013/09 – 2017/05 韩国成均馆大学,化学院,博士

2010/09 – 2013/06 济南大学,化学化工学院,硕士

2005.09 – 2009.06 巢湖学院,化学化工学院,学士

讲授课程:

基础物理化学实验 计算化学

研究方向:

1)蛋白误折叠的机理研究 (Protein Misfolding and Aggregation Mechanisms)

2)前药相关的研究 (Cancer Related Prodrugs Design)

3)二维材料的功能化以及相关模拟 (2D Materials Functionalization and Related Simulations)

4)算法开发及硬/软件优化 (Methods Developing and Hardware/Software Optimization)

主持科研项目:

4. 创新项目,2019-2021

3. 企业合作横向,2019-2021

2. 科技厅项目,2017-2020

1. 山西大学科研启动项目,2017-2020

代表性论文:(#并列一作;*通讯作者)

15. Hu Shi*, Hao Li, Wenlong Gong, Ruiting Gong, Aniu Qian, Jin Yong Lee* and Wei Guo*, Structural and Binding Properties on Aβ Mature Fibrils due to the Histidine Tautomeric Effect, ACS Chem. Neurosci. 2019, 10, 46124618

14. Xiaofeng Xing, Wei Zhao, Dingkun Hu, Baotao Kang, Hu Shi*, Jin Yong Lee*, and Hongqi Ai*, Tautomerization Effect of Histidines on Oligomer Aggregation of βAmyloid(140/42) during the Early Stage: Tautomerism Hypothesis for Misfolding Protein Aggregation, ACS Chem. Neurosci., 2019, 10, 2602-2608

13. Abbas Salimia, Hao Lia, Hu Shi*, Jin Yong Lee*, Intrinsic origin of amyloid aggregation: Behavior of histidine (εεε) and (δδδ) tautomer homodimers of Aβ (1–40), BBA - General Subjects, 2019, 1863, 795-801

12. Weicong Huang(#), Hu Shi(#), Hongguang Liu*, and Cle´mence Corminboeuf*, The influence of external electric fields on charge reorganization energy in organic semiconductors, Chem. Commun., 2019, 55, 2384-2387

11. Aniu Qian, Jung Yong Seo, Hu Shi*, Jin Yong Lee, and Chan-Hwa Chung* “Surface Functional Groups and Electrochemical Behavior in Dimethyl Sulfoxide-Delaminated Ti3C2Tx MXene” ChemSusChem, 2018, 11, 3719–3723.

10. Amit Sharma,(#) Min-Goo Lee,(#) Hu Shi(#), Miae Won, Jonathan F. Arambula, Jonathan L. Sessler,* Jin Yong Lee,* Sung-Gil Chi,* and Jong Seung Kim1* “Overcoming Drug Resistanceby Targeting Cancer Bioenergetics with an Activatable Prodrug” Chem, 2018, 4, 1–14.

09. Amit Sharma,(#) Eun-Joong Kim,(#) Hu Shi,(#) Jin Yong Lee*, Bong Geun Chung*, Jong Seung Kim* “Development of a theranostic prodrug for colon cancer therapy by combining ligand-targeted delivery and enzyme-stimulated activation” Biomaterials, 2018, 155, 145-151.

08. Ji-Ting Hou,(#) Kyung-Phil Ko,(#) Hu Shi,(#) Wen Xiu Ren, Peter Verwilst, Seyoung Koo, Jin Yong Lee,* Sung-Gil Chi,* and Jong Seung Kim* “PLK1-Targeted Fluorescent Tumor Imaging with High Signal-to-Background Ratio” ACS Sens., 2017, 2, 1512-1516.

07. Hyo Sung Jung,(#) Jiyou Han,(#) Hu Shi,(#) Seyoung Koo, Hardev Singh, Hyo-Jin Kim, Jonathan L. Sessler*, Jin Yong Lee*, Jong-Hoon Kim* & Jong Seung Kim*“Overcoming the Limits of Hypoxia in Photodynamic Therapy: A Carbonic Anhydrase IX-Targeted Approach” J. Am. Chem. Soc., 2017, 139, 7595-7602. (Cover Paper)

06. Hu Shi, and Jin Yong Lee* "Tautomeric Effect of Histidine on the Monomeric Structure of Amyloid β-Peptide(1-42)" ACS Chem. Neurosci., 2017, 8, 669-675.

05. Xiaoling Zhan,(#) Hu Shi,(#) Hongguang Liu, and Jin Yong Lee "Applying Strong External Electric Field to Thiophene-Based Oligomers: A Promising Approach to Upgrade Semiconducting Performance" J. Comput. Chem., 2017, 38, 304-311.

04. Hu Shi, Baotao Kang, and Jin Yong Lee "Tautomeric Effect of Histidine on the Monomeric Structure of Amyloid β-Peptide(1-40)" J. Phys. Chem. B, 2016, 120, 11405-11411.

03. Won Young Kim,(#) Hu Shi,(#) Hyo Sung Jung(#), Daeheum Cho, Peter Verwist, Jin Yong Lee, and Jong Seung Kim “Coumarin-decorated Schiff base hydrolysis as an efficient driving force for the fluorescence detection of water in organic solvents” Chem. Comm., 2016, 52, 8675-8678.

02. Hu Shi, Baotao Kang, Jin Yong Lee “Zn2+ Effect on Structure and Residual Hydrophobicity of Amyloid β-peptide Monomers” J. Phys. Chem. B, 2014, 118, 10355–10361.

01. Baotao Kang(#), Hu Shi(#), Shihai Yan, Jin Yong Lee, Solvent Effect on Electron and Proton Transfer in the Excited State of Hydrogen Bonded Phenol-Imidazole Complex, RSC Adv., 2014, 4, 38551-38557

Researchgate:https://www.researchgate.net/profile/Hu_Shi2

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