姓名：张立伟

职称：教授

联系方式：13603557119

介绍：

张立伟，1963.11，男，博士，山西大学分子科学研究所教授，博导，山西省学术技术带头人。国家林草局“连翘资源培育及利用研究科技创新联盟” 副理事长，山西省药学会常务理事。主要从事中药物质基础及中药资源开发研究。先后主持科技部科技支撑、中药新药创制课题以及省级课题40余项。先后在Journal of Pharmaceutical Analysis、Int. J. Mol. Sci.、Front. Pharmacol.、Ecotoxicology and Environmental Safety、Pharmaceutics、Foods等中外期刊发表论文150余篇，制订中药材标准5个。获山西省科学技术二等奖2项，技术转让中药专利成果5项。

学习与工作经历：

1990/07 -至今    山西大学，分子科学研究所，教授

2008/01 -2008/07 日本神户药科大学, 合作研究

1999/09 -2022/06 山西大学，分子科学研究所，博士

1987/09 -1990/06 山西大学，分子科学研究所，硕士

1984/09 - 1987/08 晋中师专，化学系，教师

1980/09 -1984/07 山西大学，化学系，学士

工作职责：无

研究方向：中药物质基础及中药资源开发

讲授课程：中药新药研究与开发

代表性论文：

1. Huanhuan Xue, Peijie Li, Jing Guo, Tinggui Chen, Shifei Li，and Liwei Zhang *. Phillygenin ameliorated tight junction proteins reduction, fibrosis, and apoptosis in chronic colitis mice via TGR5 mediated PERK-eIF2α-Ca2+ pathway. Journal of Pharmaceutical Analysis. 2025, 15 : 101042.

2. Huan-Huan Xue , Jing-Jing Li , Shi-Fei Li , Jing Guo , Rui-Ping Yan , Ting-Gui Chen , Xiang-Hua Shi , Jin-Dong Wang and Li-Wei Zhang*. Phillygenin Attenuated Colon Inflammation and Improved Intestinal Mucosal Barrier in DSS-induced Colitis Mice via TLR4/Src Mediated MAPK and NF-κB Signaling Pathways. Int. J. Mol. Sci., 2023, 24, 2238.

3. Lei Wu , Xiang Jin , Canwen Zheng , Fengjing Ma , Xue Zhang , Pengfei Gao , Jianhua Gao * and Liwei Zhang *.  Bidirectional Effects of Mao Jian Green Tea and Its Flavonoid Glycosides on Gastrointestinal Motility，Foods， 2023, 12, 854.

4. Lei Wu, Liming Gao , Xiang Jin , Zhikang Chen , Xutong Qiao , Xiting Cui , Jianhua Gao , and Liwei Zhang *.  Ethanol Extract of Mao Jian Green Tea Attenuates Gastrointestinal Symptoms in a Rat Model of Irritable Bowel Syndrome with Constipation via the 5-hydroxytryptamine Signaling Pathway. Foods， 2023, 12, 1101.

5. Tao Wang, YuanBo Zhang, BaiFang Wang, JianKai Tang, XueJian Guo, ShiFei Li, LingHao Qin and Liwei Zhang *. Screening of Antimicrobial Ingredients in Forsythia Leaves Using Target Constituent Knockout/Knock-in Strategy and Evaluation of the Combination Effects with Antibiotics，Natural Product Communications，2023，18(3): 1-7.

6. Shifei Li* , Xiuyi Wang, Yuqin Yang, Xingkang Wu and Liwei Zhang* . Discovering the Mechanisms of Oleodaphnone as a Potential HIV Latency-Reversing Agent by Transcriptome Profiling，International Journal of Molecular Sciences，Int. J. Mol. Sci. 2023, 24, 7357.

7. Jing Guo , Wen-Rui Yan , Jian-Kai Tang , Xiang Jin , Huan-Huan Xue , Tao Wang , Li-Wei Zhang*, Qian-Yun Sun**, Zhan-Xue Liang. Dietary phillygenin supplementation ameliorates aflatoxin B1-induced oxidative stress, inflammation, and apoptosis in chicken liver，Ecotoxicology and Environmental Safety，2022，236：113481.

8. Tao Wang, Xu-Jiong Li *, Ling-Hao Qin , Xue Liang, Huan-Huan Xue, Jing Guo, Shi-Fei Li and Li-Wei Zhang*，Better detoxifying effect of ripe forsythiae fructus over green forsythiae fructus and the potential mechanisms involving bile acids metabolism and gut microbiota，Front. Pharmacol., 2022，13: 987695.

9. Lingzhi Wang, Wenrui Yan, Yurun Tian, Huanhuan Xue, Jiankai Tang and Liwei Zhang*. Self‐Microemulsifying Drug Delivery System of Phillygenin: Formulation Development, Characterization and Pharmacokinetic Evaluation. Pharmaceutics, 2020, 12, 130.