姓名：苗俊峰

职称：副教授

联系方式：13753799530

邮箱：miaojunf@sxu.edu.cn

介绍：

      长期从事光动力治疗试剂及荧光探针的开发与生物应用研究工作，在染料的合成、功能化、生物应用方面积累了丰富的经验。近年来，致力于开发新型光敏剂和荧光探针，并将其应用于肿瘤诊断、治疗以及生物传感等领域，取得了一系列创新性成果。开发了多种新型光敏剂，具有优异的光物理化学性质和生物相容性，可高效产生活性氧，用于肿瘤的光动力治疗和抗菌治疗。研究成果分别发表在Angew. Chem. Int. Ed, Adv. Sci., Biomaterials，Chem. Sci.，, ACS Appl. Mater. Interfaces 和J. Mater. Chem. B上。

学习与工作经历：

2018/08 – 至今，山西大学，化学化工学院

2013/09 – 2018/07，山西大学，硕博连读

2007/09 – 2011/07，山西大学，学士

讲授课程：高分子化学、物理有机化学

研究方向：新型光动力治疗试剂的开发与应用；荧光探针的设计、合成与生物成像；染料的功能化修饰及其生物应用；肿瘤的早期诊断与靶向治疗

主持科研项目：

1.国家自然科学基金（青年项目）, 基于自旋轨道电荷转移增强的系间窜跃调控机制（SOCT-ISC）的新型光敏试剂的构建及肿瘤光动力治疗研究, 24万，2021.01-2023.12，结题

 2. 山西省应用基础研究计划项目，不依赖氧含量的新型肿瘤光动力治疗试剂的开发与应用，3 万，2020.1-2022.12，结题

代表性论文：

1.Heavy Atom-Free, Mitochondria-Targeted, and Activatable Photosensitizers for Photodynamic Therapy with Real-Time In-Situ Therapeutic Monitoring.Junfeng Miao, Yingying Huo*, Guangxiao Yao, Yu Feng, Jiajin Weng, Wei Zhao, andWei Guo*, Angew. Chem. Int. Ed. 2022, 61, e202201815

2. Improved Orthogonality in Naphthalimide/Cyanine Dyad Boosts Superoxide Generation: a Tumor-Targeted Type-I Photosensitizer for Photodynamic Therapy of Tumor by Inducing Ferroptosis, Guangxiao Yao, Junfeng Miao,* Yingying Huo, and Wei Guo*, Adv. Sci., 2025, 2417179.

3. Constructing Heavy-Atom-Free Photosensitizers for Hypoxic Tumor Phototherapy Based on Donor-Excited Photoinduced Electron-Transfer-Driven Type-I and Type-II Mechanisms, Junfeng Miao, Guangxiao Yao, Yingying Huo*, Beibei Wang, Wei Zhao, and Wei Guo*, ACS Applied Materials & Interfaces202416(31), 40428-40443.

4.Fast-response and highly selective fluorescent probes for biological signaling molecule NO based on N-nitrosation of electron-rich aromatic secondary amines, Junfeng Miao, Yingying Huo, Xin Lv, Zhe Li, Hualiang Cao, Heping Shi, Yawei Shi, Wei Guo*,Biomaterials,2016,78,11-19.

5.“A new class of fast-response and highly selective fluorescent probes for visualizing peroxynitrite in live cells, subcellular organelles, and kidney tissue of diabetic rats” Junfeng Miao, Yingying Huo, Qian Liu, Zhe Li, Heping Shi, Yawei Shi, Wei Guo*,Biomaterials,2016, 107,33-43.

6. A Si-rhodamine-based near-infrared fluorescent probe for visualizing endogenous peroxynitrite in living cells, tissues, and animals，Junfeng Miao, Yingying Huo, Hu Shi, Junru Fang, Juanjuan Wang and Wei Guo*，J. Mater. Chem. B,2018, 6,4466—4473.

7.Aromatic secondary amine-functionalized fluorescent NO probes: improved detection sensitivity for NO and potential applications in cancer immunotherapy studies Yingying Huo,Junfeng Miao, Junru Fang, Hu Shi, Juanjuan Wang and Wei Guo*，Chem. Sci.,2019, 10,145-152.

8.Selective and sensitive visualization of endogenousnitric oxide in living cells and animals by a Sirhodamine deoxylactam-based near-infrared fluorescent probe, Yingying Huo,Junfeng Miao, Lingjun Han, Yaping Li, Zhe Li, Yawei Shi and Wei Guo *,Chemical Science,2017, 8,6857-6864.

9.Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms, Yingying Huo, Junfeng Miao, Yaping Li, Yawei Shi, Heping Shi and Wei Guo*,J. Mater. Chem. B,2017, 5,2483—2490.

10. A novel Bodipy-based fluorescent probe for Au3+ions with high selectivity and its application to bioimaging, Yue Wang, Yawei Liu, Junfeng Miao, Minghao Ren, Wei Guo, Xin Lv*,Sensors and Actuators B,2016,226,364–369.