姓名：王文明

职称：副教授

联系方式：wangwm@sxu.edu.cn

介绍：

王文明，男，1988年生。理学博士，副教授，硕士生导师。2010年毕业于南开大学信息技术科学学院信息安全专业，获得工学学士学位。2015年毕业于南开大学生命科学学院，获得理学博士学位师从饶子和院士。任职以来，承担及参与多项国家自然科学基金项目，目前从事蛋白自组装调控、金属蛋白结构与功能研究以及基于蛋白的金属药物载运体系构建工作。相关研究成果发表在Nat Commun, J Am Chem Soc, Proc Natl Acad Sci, Angew Chem Int Ed, ACS Nano, Chinese Chemical Letters, Chem Commun, Inorganic Chemistry等国际权威期刊发表学术论文30余篇。

学习与工作经历：

2019.01- 至今   山西大学 分子科学研究所    副教授

2015.07-2018.12  山西大学 分子科学研究所    讲师

2010.09-2015.06  南开大学 生命科学学院      博士

2006.09-2010.06  南开大学 信息技术科学学院  本科

工作职责：

无

研究方向：

金属蛋白的结构与功能研究、蛋白质结构设计

讲授课程：

蛋白质化学、现代生化技术、化学生物学等

主持科研项目：

承担项目：

1.山西省科学技术厅, 面上项目, 20210302123433, 肺炎支原体锌离子吸收调控蛋白Zur功能的结构基础和分子机制研究, 2021-07 至 2024-06, 9.00万元，主持，结题。

2. 医药生物技术山西省重点实验室开放课题，血清白蛋白与ATX抑制剂复合体结构生物学研究及应用。KF202003，2020.01-2021.12，4.9万元，主持，结题。

3. 山西省高等学校科技创新项目。耐热型碳酸酐酶结构与酶学性质研究，2019L0020，2020.01-2021.12，3万元，主持，结题。

4.国家自然科学基金青年基金项目。21601112，锌离子调控肠道病毒EV71 2A蛋白酶生物活性的分子机制研究，2017.01-2019.12，20万元，主持，结题。

代表性论文：

1. Ma Danyang, Yao Hui, Liu Yuhua, Gong Wenjun, Zhao Yaqin, Wang Ruiying, Wu Changxin, Wang Wenming*, Wang Hongfei*. The reduced interaction between SufS and SufU in Mycoplasma penetrans results in diminished sulfotransferase activity. International Journal of Biological Macromolecules, 2025, 284, 138181.

2. Wang Wenming, Xi Hongfang, Fu Dan, Ma Danyang, Gong Wenjun, Zhao Yaqin, Li Xiaomei, Wu Lijie, Guo Yu, Zhao Guanghua, Wang Hongfei. Growth process of Fe-O nanoclusters with different sizes biosynthesized by protein nanocage. Journal of the American Chemical Society, 2024, 146, 11657−11668.

3. Fu Dan, Wang Wengming, Zhang Yan, Zhang Fan, Yang Chun, Tian Yufei, Yao Renqi, Jian Jingwu, Sun Zixian, Zhang Nan, Ni Zhiyu, Rao Zihe, Zhao Lei, Guo Yu. Self-assembling nanoparticle engineered from the ferritinophagy complex as a rabiesvirus vaccine candidate. Nature Communications, 2024, 15, 8601.

4. Wang wenming, Wang Yuan, Xi Hongfang, Song Zidan, Zhang Wenlong, Xie Leilei, Ma Danyang, Qin Nan, Wang Hongfei. Extension Peptide of Plant Ferritin from Setaria italica Presents a Novel Fold. Journal of Agricultural and Food Chemistry, 2023, 71, 934−943.

5. Bai Hehe, Gong Wenjun, Pang Yating, Shi Chaoyang, Zhang Zhigang, Guo Lili, Li Yafeng, Wang Wenming*, Wang Hongfei*. Synthesis, cytotoxicity, and biomacromolecule binding: Three isomers of nitrosylruthenium complexes with bidentate bioactive molecules as co-ligands. International Journal of Biological Macromolecules, 2023, 243:125009.

6. Wang Wenming, Liu xiaojia, Wang Yajie, Wang Yuan, Fu Dan, Xi Hongfang, Zhao Yi, Wang Hongfei. Distinct structural characteristics define a new subfamily of Mycoplasma ferritin. Chinese Chemical Letters, 2022, 33: 4952–4955.

7. Wang Deping, Wang Meiyue, Li Yongmei, Wen Shu, Cui Wen, Jiang Fangying, Zhou Xin*, Wang Wenming*, Cao Jimin*. Crystal structure of the Ilheus virus helicase: implications for enzyme function and drug design. Cell & Bioscience (2022) 12:44.

8. Wang Wenming, Zhang Yao, Zhao Guanghua, Wang Hongfei. Ferritin with Atypical Ferroxidase Centers Takes B-Channels as the Pathway for Fe²⁺ Uptake from Mycoplasma. Inorganic Chemistry, 2021, 60, 10, 7207-7216.

9. Cui Xiaodong*, Wang Ke, Wang Tingfen, Li Jiao, Li Chen, Wang Wenming*, Wang Hongfei, Wang Zhuanhua. Crystal Structure Analysis of Cationic Peroxidase from Proso Millet and Identification of Its Phosphatase Active Sites, Journal of Agricultural and Food Chemistry, 2021, 69(22): 6251-6259.

10. Wang Wenming, Wang Lele, Li Guobang, Zhao Guanghua, Zhao Xuan, Wang Hongfei. AB loop engineered ferritin nanocages for drug loading under benign experimental conditions., Chemical Communications, 2019, 55(82):12344-12347.

11. Wang Wenming, Wang Lele, Chen Hai, Zang Jiachen, Zhao Xuan, Zhao Guanghua, Wang Hongfei. Selective Elimination of the Key Subunit Interfaces Facilitates Conversion of Native 24-mer Protein Nanocage into 8-mer Nanorings, Journal of the American Chemical Society, 2018, 140:14078-14081.

12. Zhou Kai, Zang Jiachen, Chen Hai, Wang Wenming, Wang Hongfei, Zhao Guanghua. On-Axis Alignment of Protein Nanocage Assemblies from 2D to 3D through the Aromatic Stacking Interactions of Amino Acid Residues. ACS Nano, 2018，12, 11323-11332.

13. Zhang Shengli, Zang Jiachen, Wang Wenming, Chen Hai, Zhang Xiaorong, Wang Fudi, Wang Hongfei, Zhao Guanghua. Conversion of the Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues. Angewandte Chemie International Edition, 2016, 55(52): 16064-16070.

14. Wang Wenming; Liu Xiang; Wang Xu, Dong Hui, Ma Chao, Wang Jingmin, Liu Baocheng, Mao Yonghong, Wang Ying, Li Ting, Yang Cheng, Guo Yu. Structural and Functional Diversity of Nairovirus-Encoded Nucleoproteins. Journal Of Virology, 2015, 89(23): 11740-11749.

15. Guo Yu, Wang Wenming, Sun Yuna, Ma Chao, Wang Xu, Wang Xin, Liu Pi, Shen Shu, Li Baobin, Lin Jianping, Deng Fei, Wang Hualin, Lou Zhiyong. Crystal Structure of the Core Region of Hantavirus Nucleocapsid Protein Reveals the Mechanism for Ribonucleoprotein Complex Formation. Journal Of Virology, 2016, 90(2): 1048-1061.

16. Guo Yu, Wang Wenming, Ji Wei, Deng MaPing, Sun Yuna, Zhou Hongfang, Yang Cheng, Deng Fei, Wang Hualin, Lou Zhiyong, Rao Zihe. Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses. Proc Natl Acad Sci USA, 2012, 109(13): 5046-5051.